In the area of characterizing the genetic architecture of complex traits, the relatively new field of bioinformatics is distinguished from the more mature fields of statistical genetics or genetic epidemiology by its focus on genome-wide data. Consensus Report: Chronic Periodontitis. Search. In addition, oral bacterial products or cytokines in oral/pharyngeal aspirates may stimulate cytokine production from respiratory epithelial cells, resulting in recruitment of inflammatory cells. Within the last 18 months, one case-control study and one longitudinal study have reported finding positive associations that were not statistically significant. BMP4 micro‐immunotherapy increases collagen deposition and reduces PGE2 release in human gingival fibroblasts and increases tissue viability of engineered 3D gingiva under inflammatory conditions This accumulation has been linked to the development of pathogenic complications of diabetes. The use of preoperative antibiotics was nearly significant to implant survival (P = 0.051. Annals of periodontology. annals periodontology - Read articles from Issue 2002(12). Meta-analyses were performed for studies that fulfilled the eligibility criteria for the following continuous variables: clinical attachment level (CAL), probing depth (PD), or bone level (radiographic, re-entry, or histologic). Studies involving the use of low-dose doxycycline, combinations of locally plus systemic antibiotics, or where the control group included a systemically administered antibiotic were excluded. 20: Concerns appear in the literature that HA-coated implants experience greater breakdown because they are more susceptible to bacterial colonization due to their roughness and hydrophilicity. The need for help in brushing one's teeth could reflect the fact that many subjects had reduced manual dexterity as a result of the CVA and required this extra care. However, if complete regeneration is to become a reality, additional stimuli to enhance the regenerative process are likely needed. We haven't found any reviews in the usual places. These findings are consistent with the current model of how genetic factors influence common chronic diseases. Although carefully collected, accuracy cannot be guaranteed. The mandibular edentulous strata produced success rates of 98.1% for the fixed hybrid prosthesis to 91.7% for the cap-retained prosthesis. Variations in the defects selected for study may also affect predictability of outcomes along with other factors. WorldCat Home About WorldCat Help. Each issue contains proceedings of a meeting or symposium of interest to dental researchers, educators, and students. Chicago, Ill. : American Academy of Periodontology, c1996-description. The association between diabetes mellitus and periodontal disease has long been discussed, with conflicting conclusions. The changes in stability found in BQ-1, BQ-2, and BQ-3 were similar, with HA implants becoming less stable and non-coated more stable. Well-designed and well-controlled studies done in the EC, US, and other developed countries are generally accepted throughout the world. Results were assessed with both fixed-effects and random-effects models. When considering the post-loading approach, the titanium-alloy screw had the highest survival (99.4%), with the HA-cylinder having the next highest survival (98.6%). The DICRG comprised 30 VA medical centers and 2 dental schools at the time of this study. Periodontol.It is the recommended abbreviation to be used for abstracting, indexing and referencing purposes and meets all criteria of the ISO 4 standard for abbreviating names of scientific journals.. Indication and claim support of the antimicrobial product guide the design and implementation of the CT. Contents. In PMA-stimulated cells exposed to smoke, there was a time-related inhibition of both superoxide and H2O2 production. What people are saying - Write a review. American Academy of Periodontology. The combined results were statistically significant (P < 0.001). Diabetics had significantly higher GCF levels of both PGE2 and IL-1 beta when compared to non-diabetic controls with similar periodontal status. 63, Nr. Journal of Indian Society of Periodontology (JISP) is a peer-reviewed, open-access journal with an aim to convey scientific progress in periodontology and is dedicated to global and extensive publication for the benefit of oral health. We propose that an infection-media … Given the underlying biological plausibility, the cumulative lifetime burden of chronic pathogens may be expected to create risk of atherosclerosis and thrombosis, and, indirectly, signs of cardiovascular disease. 4. Read article PDFs using your inistitution's subscriptions with no additional login. Narrowing of and increased detail in the phosphate peaks indicated an increase in average crystal size and/or perfection relative to the controls, as did the XRD results. Evidence from many sources links preterm birth to symptomatic infections, for example, of the urinary or respiratory tracts. 5. Mean stability values (PTVs) increased incrementally from -4.5 at uncovering to +1.1 at 36 months, indicating a decrease in stability of the bone-implant-prosthesis complex. This systematic review evaluates literature-based evidence in an effort to determine the efficacy of currently available anti-infective agents, with and without concurrent SRP, in controlling chronic periodontitis. It is generally accepted that diameter and length of an endosseous dental implant and its stability at placement are critical factors in achieving and maintaining osseointegration. There is an increase in prevalence and severity of periodontitis compared to controls. Annals of Periodontology Volume 1, Issue 1. The Academy, 2000 - Periodontics. In the event of slight implant mobility at placement, the conventional or accepted treatment is to place a longer implant and/or one of wider diameter. Improvements in mean AL were consistent for both chronic and aggressive periodontitis subjects, although the aggressive periodontitis patients benefited more from the antibiotics. HA-coated implants demonstrated the highest survival rate; 2) the post-loading analysis approach inflated survival; 3) non-HA implants showed increased stability following loading; 4) HA-coated implants showed a slight decrease or no change in stability; and 5) the clinical significance of the changes in implant stability must be determined for the long-term. What people are saying - Write a review. A novel finding in unstimulated cells exposed to smoke was that there appeared to be 2 distinct populations of cells--one of "high" H2O2 producers and one of "low" H2O2 producers. The dental findings relative to the prevalence of dental caries and periodontal disease were not distinctly different between the subjects with and without a CVA in the bivariate analysis. DOI: 10.1902/annals.1998.3.1.51 Abstract Severe periodontal disease often coexists with severe diabetes mellitus. 17: Brian W Bainbridge Stephen R Coats Richard P Darveau . Periodontal diseases are infections and thus systemically administered antibiotics are often employed as adjuncts for their control. In vitro aging of human gingival fibroblast (HGF) and periodontal ligament fibroblast (HPLF) cells was prepared by sequential subcultivations (5 to 6 passages as young, 18 to 20 passages as old). The Office of Device Evaluation (ODE), within the Center for Devices and Radiological Health of the Food and Drug Administration is the primary component responsible for the premarket review of medical devices. Therapeutic interventions had to include 1) SRP alone; 2) local anti-infective drug therapy and SRP; or 3) local anti-infective drug therapy alone. Longer implants demonstrated higher survival than shorter implants. All root canals contained anaerobic bacteria. It is likely that therapy directed at preventing or treating underlying causes would be more successful. Searches were limited to human studies published in English. Within diabetics, LPS dose-response curves demonstrated that monocytes from group B patients secreted approximately 3 times more PGE2 and 6.2 times more TNF-alpha than those from group A; however, there was no significant difference in monocytic IL-1 beta secretion between the 2 diabetic groups. Read article PDFs using your inistitution's subscriptions with no additional login. Gingivitis patients and mild periodontitis patients represented one low response group, and the moderate and severe periodontitis subjects the high response group. The data supported similar effect sizes for the majority of the antibiotics; therefore, the selection for an individual patient has to be made based on other factors. Periodontal tissue engineering utilizing growth and amelogenin-like factors (GAFs) applies advances in materials science and biology to regenerate alveolar bone, periodontal ligament, and cementum. Search. Three retrieved dental implant specimens from humans following clinical failure due to peri-implantitis were examined. [iso] Ann Periodontol [dnlm] Ann. What people are saying - Write a review. Results of Longitudinal Testing to 60 Months With the Periotest Device on Endosseous Dental Implants, Long-Term Assessment (5 to 71 Months) of Endosseous Dental Implants Placed in the Augmented Maxillary Sinus, Enhanced Interaction of Advanced Glycation End Products With Their Cellular Receptor RAGE: Implications for the Pathogenesis of Accelerated Periodontal Disease in Diabetes, Receptor for Advanced Glycation End Products, Inflammation, and Accelerated Periodontal Disease in Diabetes: Mechanisms and Insights Into Therapeutic Modalities, The Relationship Between Dental Disease and Cerebral Vascular Accident in Elderly United States Veterans, Voluntary Programs: ADA Seal Program and International Implications, Oral Bacteria and Respiratory Infection: Effects on Respiratory Pathogen Adhesion and Epithelial Cell Proinflammatory Cytokine Production, An Overview of Food and Drug Administration Regulation of Drugs, Biologies, and Devices to Be Used for Management of Periodontal Diseases, The Food and Drug Administration and the Regulation of Clinical Trials for Endosseous Implants*, Genetic Variations in Cytokine Expression: A Risk Factor for Severity of Adult Periodontitis, The Relationship Between Infections and Adverse Pregnancy Outcomes: An Overview, The Pathobiology of Periodontal Diseases May Affect Systemic Diseases: Inversion of a Paradigm, Variables Affecting Survival of Single-Tooth Hydroxyapatite-Coated Implants in Anterior Maxillae at 3 Years, Overview of Periodontal Clinical Trials Utilizing AntiInfective or Host Modulating Agents, Local Anti-Infective Therapy: Pharmacological Agents. The PC group had glycosylated hemoglobin (HbA1) > or = 9%; the BC group had HbA1 < 9%. In addition, oxygen radical-treated fibronectin (FN) as substratum diminished bone nodule formation by osteoblasts when compared with intact FN. All the cases were successfully restored with implant-supported, bar-retained overdentures or fixed partial dentures. The majority of the remaining papers had a low evidence rating. 4. The use of endosseous dental implants to replace natural teeth lost to trauma, dental caries, or periodontal disease has become a predictable form of prosthetic treatment since gaining popularity in the early 1980s. The concerns about HA-coated implants being associated with adverse periodontal responses for the HA chemical composition included in this study appear to be unfounded for a period of clinical performance up to 36 months. Observing and communicating with the patient is the most important means of monitoring the patient's status during sedation. The finding that host modifying factors are associated with severe periodontitis suggest a biological mechanism by which some individuals, if challenged by bacterial accumulations, may have a more vigorous immunoinflammatory response, leading to more severe clinical disease. annals periodontology - Read articles from Issue 1997(03). In this report, we will review our studies to date on AGEs and RAGE and consider the implications of their enhanced interaction in the pathogenesis of accelerated periodontal disease in diabetes. Annals of periodontology. This study attempted to determine if Type 2 diabetes represents a significant risk factor to the long-term clinical performance of dental implants, using the comprehensive DICRG database. Country: United States - 71. Pathogenetic mechanisms include an ascending route of infection and/or inflammatory process due to microbial products and maternal and/or fetal response(s) with production of prostaglandins and cytokines. Annals of Periodontology. and you may need to create a new Wiley Online Library account. Read article PDFs using your inistitution's subscriptions with no additional login. Other reports, however, relate favorable responses to HA-coated implants, which include rapid bone adaptation to the HA, greater stability at uncovering, and increased coronal bone growth. In hyperglycemic states found in diabetics, a nonenzymatic glycation and oxidation of proteins and lipids occurs. From inside the book . We haven't found any reviews in the usual places. Diabetes was a possible exclusion criterion; however, the final decision on Type 2 patients was left to the dental implant team at the research center. Proceeding of the 1996 World Workshop in Periodontic. Annals of Periodontology, Volume 6. Implant survival was higher in those placed in grafted sinuses (97.5%) than in those placed in the posterior maxilla without sinus grafting (90.3%). It can be assumed that in each of these jaw regions, the conditions associated with both implant surface types would be similar enough to permit meaningful comparisons of periodontal-type measurements that have not previously been reported. Search for Library Items Search for Lists Search for Contacts Search for a Library. Alternatively, some microbes can directly trigger platelet aggregation in vitro and in animal models, suggesting direct prothrombotic potential in human cardiovascular disease. 8. A Systematic Review, Annals of Periodontology, December 2003, Vol. We report here information obtained from a cross-sectional study of 401 veterans, who were at least 60 years of age, which showed that several dental/oral conditions can be significantly associated with the diagnosis of a cerebral vascular accident (CVA), when included in a multivariate logistic regression model with and without many of the known risk factors for a CVA. LPS and viable Gram-negative bacteria from the biofilms and proinflammatory cytokines from the inflamed periodontal tissues may enter the circulation in pathogenic quantities. Data for all 3 mm to 3.9 mm diameter implants were pooled into a "3+" group, and the 4 mm to 4.9 mm diameter implants into a "4+" mm group. As a result, advanced glycation end products (AGEs), particularly N epsilon-(carboxymethyl)lysine, accumulate in the plasma and tissues of diabetic subjects. Randomized controlled clinical trials (RCTs), cohort studies, case-control studies, case reports, and preclinical (animal) randomized controlled investigations that included a cohort population diagnosed with periodontal disease and presenting data on intrabony/interproximal defects and/or furcation defects were screened. 1. Use of electrocardiograms is recommended for the patients with cardiovascular disorders. Yésica A. Villa‐Correa, Diana M. Isaza‐Guzmán and Sergio I. Tobón‐Arroyave, Prognostic Value of 8‐Hydroxy‐2′‐Deoxyguanosine and Human Neutrophil Elastase/α1‐Proteinase Inhibitor Complex as Salivary Biomarkers of Oxidative Stress in Chronic Periodontitis, Journal of Periodontology, 86, 11, (1260-1267), (2015). Evidence indicates that mechanical removal of subgingival infection does not result in complete elimination of periodontal infection and consequently there is no effect on diabetes control measured as reduction in glycated hemoglobin. ISSN: 1553-0841: OCLC Number: 1135237621: Notes: Titre de la couverture Chaque livraison porte également un titre distinct. 1. Proceeding of the Sunstar‐Chapel Hill Symposium ′97 on Periodontal Disease and Human Health: New Direction in Periodontal Medicine. The very dense sets of genetic markers now available, particularly those at single nucleotide positions (SNPs), have meant that it is possible to seek linkages or associations between chromosomal position and disease from the whole genome in a single study. In vitro exposure to smoke involved incubating aliquots of neutrophils in phosphate-buffered saline for 1 to 5 minutes. Annals of Periodontology, Volume 7 Snippet view - 2002. Possible clustering was also studied. Annals of Periodontology - Dentistry. The aim of this study was to use phenotypic and genetic methods to trace microorganisms released into the bloodstream during and after endodontic treatment back to their presumed source--the root canal. Clinical trials of anti-cytokine and anti-inflammatory drugs to treat shock are now designed and conducted taking strategic advantage of this knowledge by including measurements of microbial dose and host response. In sum, a large body of clinical and laboratory information suggests that subclinical infection is a major cause of preterm birth, especially those occurring before 30 weeks. Well-controlled diabetic patients as measured by blood glycated hemoglobin levels have less severe periodontal disease than poorly controlled diabetics. Periodontal-type measurements (gingiva, plaque, suppuration, and calculus indices; probing depth; attachment levels; recession; and keratinized tissue width) for each aspect of each implant (mesial, facial, distal, and lingual) were recorded at 3, 6, 9, 12, 18, 24, and 36 months following implant uncovering. Department of Periodontics, Health Sciences Center, University of Texas, San Antonio, Texas. The use of supplemental oxygen is recommended. Nicotine and cotinine levels were quantitated using gas chromatography, with detection by electron impact mass spectrometry. Of the 1,118 medically healthy dentate men at baseline, 261 subsequently developed COPD. The study protocol specified that the implants be randomized to various jaw regions to accomplish the primary goals of the study--the comparison of each implant design's overall survival. From inside the book . Annals of Periodontology Volume 8, Issue 1. Common abbreviations: Ann Periodontol [DE-600] Ann. Currently, clinical attachment level measurements and alveolar bone assessments are accepted as proof of effectiveness. Title proper: Annals of periodontology. Periodontol. 3. Survival was also determined for each of the three phases of implant treatment--phase 1, from the time of placement to uncovering and abutment connection; phase 2, from uncovering to placement and loading of the prosthesis; and phase 3, from loading of the prosthesis to 36 months. 0 Reviews. We have recently examined the gingival crevicular fluid (GCF) mediator level, monocytic secretion, and clinical presentation of 39 insulin-dependent diabetes mellitus (IDDM) patients and 64 non-diabetic patients with various degrees of periodontal health and disease. Because the life expectancy of individuals continues to increase, dentists providing dental implant treatment can expect to see an increasing number of patients with diabetes mellitus. Evidence is conclusive (Table 2) that periodontal regeneration in humans is possible following the use of bone grafts, guided tissue regeneration procedures, both without and in combination with bone grafts, and root demineralization procedures. Here again the literature is unclear; however, a recent development suggests that effective control of periodontal infection in patients with diabetes reduces the level of advanced glycosylation end products in the serum. Eight studies, representing 7 RCTs and 1 quasi-experimental study, representing a total population of 511 subjects were analyzed with respect to EMD. HGF and HPLF cells were treated with lipopolysaccharide (LPS) and cyclic tension force, respectively. Role of Nuclear FactorKappa B NFKB in Inflammation Periodontitis and Atherogenesis . More than 2,900 HA-coated and non-HA implants were randomized as to location within one of three jaw regions--maxillary anterior, mandibular anterior, and mandibular posterior--and followed for 36 months. Annals of Periodontology Volume 3, Issue 1. These prostheses were divided into five research strata based on arch location. In conclusion, our data suggest that diabetic patients have exaggerated inflammatory responses when compared to non-diabetic controls. 1 Subsequently, a simpler classification was agreed upon at the 1 st European Workshop in Periodontology. Maintenance of mean clinical attachment level should be a primary outcome measure for all prevention studies of adult periodontitis. A total of 30 VA medical centers and 2 dental schools combined to form the Dental Implant Clinical Research Group (DICRG). For new drug products, clinical trials are carried out under an approved Investigational New Drug Application (IND). Line Chart . The evidence supports the notion that treatment of chronic periodontal infection is essential in the diabetic patient. Canadian, and Japanese regulations are most important for United States (US) scientists attempting to globalize their research. All implants in bone qualities 1 and 2 (BQ-1 and BQ-2) became more stable over time, while those in bone quality 3 or 4 (BQ-3 and BQ-4) showed a slight decrease in stability. Within the diabetic group, the GCF levels of these inflammatory mediators were almost 2-fold higher in group B subjects when compared to diabetics from group A. Sponsors need to carefully consider each step in the overall development plan beginning with an Investigational New Drug Application and concluding with submission of a New Drug Application for pre-market approval. Logistic regression analysis was used to determine the independent contribution of bone loss measurement at baseline to the subsequent risk of developing COPD over a 25-year follow-up period. The augmentation materials were autogenous bone, allogenic bone (demineralized freeze-dried bone allograft, DFDBA), alloplastic bone (HA), combination grafts of HA and DFDBA, and combination grafts of autogenous bone and DFDBA. Future Phase IV clinical trials should be designed that evaluate local anti-infective therapies in conjunction with SRP in a manner consistent with current standards of care and evaluate cost-effectiveness. While it is the objective of the Scheme for the Mutual Recognition of Evaluation Reports on Pharmaceutical Products and the EC Decentralized Procedure, it is not apparent when the FDA will totally accept another regulatory body's approval decision. For each bone quality, there was a significant difference in implant survival for the non-coated implants (P < 0.01). In addition, IL-1 is a strong enhancer of tissue levels of PGE2 and TNF-alpha. Failures appeared to be associated with a history of smoking. From inside the book . Survival rates from placement to 36 months were reported for the ongoing Dental Implant Clinical Research Group studies of root-form endosseous dental implants. 2. According to RT-PCR analysis, gene expression of COX-2, IL-1 beta, IL-6, and tissue type (t) PA was higher in old cells than in young cells. View all » Bibliographic information. DOI: 10.1902/annals.2003.8.1.54 Abstract Background: Several recent studies provide evidence that the oral cavity may influence the initiation and/or the progression of lung diseases such as pneumonia and chronic obstructive pulmonary disease (COPD). 0 Reviews. Annals of Periodontology, Volume 7 Snippet view - 2002. HA- and non-coated comparisons were not possible in BQ-4 since there were too few non-coated implants placed in this type of bone. The systemic antibiotics were uniformly beneficial in providing an improvement in AL when used as adjuncts to scaling and root planing (SRP) and were consistently beneficial, although of borderline significance, when used as adjuncts to SRP plus surgery or as a stand alone therapy. Prevention studies of periodontitis require a longer duration than treatment studies. Studies have provided evidence that hormones, heredity, and other host factors influence periodontal disease incidence and severity. A total of 2,887 implants (663 patients) were surgically placed, restored, and followed for a period of 36 months. The purpose of this paper was to document changes in PTVs as influenced by various implant surfaces, implant designs, and bone densities. The earlier studies stimulated a number of studies focused on identifying potential biological mechanisms that might underlie this association. These characteristics differed between patients. Ira Lamster. Xuan Zhou, Jing Han, Zhiqiang Liu, Yiqing Song, Zuomin Wang and Zheng Sun, Effects of periodontal treatment on lung function and exacerbation frequency in patients with chronic obstructive pulmonary disease and chronic periodontitis: A 2‐year pilot randomized controlled trial, Journal of Clinical Periodontology, 41, 6, (564-572), (2014). In some cases manufacturers have needed to provide clinical data in the form of Investigational Device Exemptions (IDE) to support an equivalence determination. It is not uncommon for the placement of endosseous dental implants in the maxillary posterior jaw region to be complicated by the pneumatization of the maxillary sinus. Our findings demonstrated that while attachment loss, probing depth, (PD) and bleeding on probing (BOP) are individually associated with sICAM and CRP, only BOP remains significant for sICAM when all 3 are in the model and, for CRP, only PD remains significant. Periodontitis is a collection of chronic inflammatory diseases that are caused by specific bacteria. Survival curves were used to determine differences in survival outcomes for the two methods. Periodontitis is an infection that is twice as prevalent in diabetic individuals compared to non-diabetics. MEDLINE. 3. For all implants included in the study, survival curves illustrated different failure patterns for each method of determining overall survival. EMD appears to be safe for single and multiple administrations in terms of lack of elicitation of antibody responses or other local/systemic inflammatory events. A mean difference in AL between groups was available for all papers used in the meta-analysis. Hydroxyapatite (HA)-coated implants had an overall failure rate of 3.9% over 36 months in all bone qualities combined, while non-coated implants had a 13.4% failure rate for the same parameters. Genetic Variations in Cytokine Expression: A Risk Factor for Severity of Adult Periodontitis. The stability of thermally processed hydroxyapatite coatings for oral and orthopedic bioprostheses has been questioned. After a series of reversible reactions which lead to the generation of Schiff bases/Amadori products, a further series of complex molecular rearrangements ensues which results in the formation of the irreversible advanced glycation end products, or AGEs. Success rates for the maxillary edentulous stratum ranged from 94.6% for the bar-retained overdenture supported by five to six fixtures to 81.8% for the cap-retained overdenture. Arie J. van Winkelhoff, Carolien J. Tijhof, and J. de Graaff, Microbiological and Clinical Results of Metronidazole Plus Amoxicillin Therapy in Actinobacillus actinomycetemcomitans-Associated Periodontitis, Journal of Periodontology, January 1992, Vol. 6. Further research is necessary to evaluate GTR procedures compared to, or combined with, bone grafts in treating intraosseous defects. These results suggest that poorer glycemic control leads to both an increased risk for alveolar bone loss and more severe progression over those without type 2 DM, and that there may be a gradient, with the risk for bone loss progression for those with better controlled type 2 DM intermediate to the other 2 groups. Bacterial vaginosis (BV) is a clinical syndrome based on an altered genital microflora in which Gardnerella vaginalis; anaerobic species primarily among Prevotella, Porphyromonas, Bacteroides, Peptostreptococcus, and Mobiluncus; Mycoplasma hominis; and Ureaplasma urealyticum become predominant in vaginal secretions. Among diabetics, GCF TNF-alpha levels were only marginally detectable and no significant difference was found between group A and group B patients. Annals of Periodontology, Volume 4, Issue 1 Snippet view - 1999. The influence of stresses transmitted to various bone densities, by different prosthetic appliances as well as the method used to determine failures, needs to be clearly understood. 3. The European Community (EC). However, caution is recommended because the data were obtained from a convenience sampling of older veterans and may not be generalizable to other populations. Medium: Online. Mutual recognition of marketing approvals is the ultimate goal for the globalization of drug research. Implant length correlated positively with 3-year survival (P = 0.003, exact test). 0 Reviews. Preclinical and initial clinical data for growth factors appear promising but are insufficient to draw definitive conclusions at this time. From inside the book . Success rates for maxillary and mandibular posterior fixed partial dentures were 94.3% and 92.6%, respectively, while the maxillary anterior single-tooth prosthesis yielded a success rate of 98.1% for the 36-month observation period. Covariates included measures of smoking, height, age, education, and alcohol consumption. Annals of Periodontology, Volume 4, Issue 1 Snippet view - 1999. Microbiological samples were taken from the root canals of 26 patients with asymptomatic apical periodontitis of single-rooted teeth. Bestellen . annals periodontology - Read articles from Issue 2002(12). Additional RCTs are needed which evaluate the effectiveness of these therapies in all forms of periodontitis. 3. A Systematic Review, Design and Implementation of Clinical Trials of Antimicrobial Drugs and Devices Used in Periodontal Disease Treatment, A Methodological Study for the Analysis of Apatite-Coated Dental Implants Retrieved From Humans, Influence of Two Different Approaches to Reporting Implant Survival Outcomes for Five Different Prosthodontic Applications, Bioinformatics and Approaches to Identifying Polygenic Susceptibility Traits, Periodontal Regeneration Around Natural Teeth, Factors Associated With Radiographic Vertical Bone Loss Around Implants Placed in a Clinical Study, Regulatory Issues for Evaluation of Therapies to Prevent or Arrest Disease Progression*, International Regulatory Aspects of Clinical Periodontal Research, Epidemiological and Clinical Aspects of Periodontal Diseases in Diabetics, Treatment of Periodontal Disease and Control of Diabetes: An Assessment of the Evidence and Need for Future Research, The Association Between Periodontal Diseases and Cardiovascular Diseases: A State-of-the-Science Review, Periodontal Diseases and Osteoporosis: Association and Mechanisms, Preterm Birth: Associations With Genital and Possibly Oral Microflora, Relationships Among Clinical Measures of Periodontal Disease and Their Associations With Systemic Markers, instructions how to enable JavaScript in your web browser. 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