Last updated on Dec 1, 2019. Ten (10) vials of Caffeine Citrate Oral Solution are packaged in a child-resistant container. Regular price $ 22.50 Sale price $ 22.50 Regular price $ 25.00 Unit price / per . Odorless. Although the mechanism of action of caffeine in apnea of prematurity is not known, several mechanisms have been hypothesized. Taurine is the main ingredient in sports drinks. After you remove your baby’s dose, throw away the open bottle (vial) and all medicine left in it. The 1/4 oz mark on the dosing chamber contains 7.5ml, which is 75mg caffeine. Micro Labs Limited The main ingredient of Caffeine Citrate Oral Solution is caffeine citrate. Overall, the reported number of adverse events in the double-blind period of the controlled trial was similar for the caffeine citrate and placebo groups. But your best guide is how caffeine makes you feel. These tri-blend shirts look & feel great! Description 16 ounces of Liquid Caffeine. A single serving will give you about the same amount of caffeine that you get from a cup of coffee. How do I give Caffeine Citrate Oral Solution to my baby? Elimination: In young infants, the elimination of caffeine is much slower than that in adults due to immature hepatic and/or renal function. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Pull the metal ring away from the vial and then pull it down towards the bottom of the vial without twisting the ring. Caffeine is readily available in the American diet. Just a squeeze will transform plain water into an instant blue citrus drink with the fruity flavor you love. If your baby develops one or more of the following symptoms, speak with your baby’s doctor right away: The following symptoms may be caused by serious bowel or stomach problems. $21.96 #25. Treatment of caffeine overdose is primarily symptomatic and supportive. In this 10 to 12 day trial, the mean number of days with zero apnea events was 3 in the caffeine citrate group and 1.2 in the placebo group. We comply with the HONcode standard for trustworthy health information -. Put a few drops in your ice cube tray to enhance or compliment drinks. For single dose only. Caffeine is structurally related to other methylxanthines, theophylline and theobromine. To open a vial of Caffeine Citrate Oral Solution: To remove the prescribed dose from the vial: You will need a small syringe to measure the exact amount of medicine that your baby’s doctor prescribed. Caffeine Citrate Oral Solution should be clear and colorless. In adults, the mean plasma protein binding in vitro is reported to be approximately 36%. Retinopathy of Prematurity. Each gift box comes with 3 Singles each of: Citrus Ginger, Sweet Peppermint, Aloha Pineapple Chamomile, Ginger Peach Cobbler and Turmeric for a total of 15 Drops. (See CLINICAL PHARMACOLOGY, Elimination, Special Populations). Micro Labs Limited In addition, long-term exposure to high oral doses of caffeine (3 g over 7 weeks) was toxic to rat testes as manifested by spermatogenic cell degeneration. Use each vial of Caffeine Citrate Oral Solution for only one dose. Most of us know we should be drinking more water. In neonates, the T1/2 is approximately 3 to 4 days and the Ae is approximately 86% (within 6 days). The vials of Caffeine Citrate Oral Solution, USP are sealed with a gray rubber stopper and a peel-off aluminum overseal with a blue flip-off polypropylene disk inset. While holding the ends of the bottom-half of the container with both hands, place both index fingers on the two semicircular locking tabs on the sides of the container. Do not use vials that contain cloudy or discolored medicine, or any visible particles. SweetLeaf Water Drops Conclusion. Convulsions may be treated with intravenous administration of diazepam or a barbiturate such as pentobarbital sodium. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. If you want more information about Caffeine Citrate Oral Solution, speak with your baby’s doctor or pharmacist. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Your baby’s doctor will prescribe the right amount of Caffeine Citrate Oral Solution based on your baby’s weight and age. Aisles Online has thousands of low-price items to choose from, so you can shop your list without ever leaving the house. Caffeine metabolism in preterm neonates is limited due to their immature hepatic enzyme systems. Colorless. Vitamins … A 1 mL/kg (20 mg/kg caffeine citrate providing 10 mg/kg as caffeine base) loading dose of caffeine citrate was administered intravenously, followed by a 0.25 mL/kg (5 mg/kg caffeine citrate providing 2.5 mg/kg of caffeine base) daily maintenance dose administered either intravenously or orally (generally through a feeding tube). The following table summarizes the clinically relevant endpoints evaluated in this study: 1 Of 85 patients who received drug, 3 were not included in the efficacy analysis because they had < 6 apnea episodes/24 hours at baseline. You might not want to know how much caffeine a venti has. For me I am happy with plain water, and have a 30-oz TupperWare cup at my desk all day to offset the heat/AC vent blowing dry air about six feet away from me. Caffeine citrate should be administered with caution in preterm neonates with impaired renal or hepatic function. Yes, you can buy a water enhancer—a little bottle of colorful liquid to squeeze in your water that marketers say add B vitamins and other vitamins and minerals—but let's be clear, most of these flavor squeezers are just artificial chemical concoctions that don't do anything to enhance the properties of water. You’ll have to try it to believe it, but Water Joe tastes like water. Other causes of apnea (e.g., central nervous system disorders, primary lung disease, anemia,sepsis, metabolic disturbances, cardiovascular abnormalities, or obstructive apnea) should be ruled out or properly treated prior to initiation of caffeine citrate. A therapeutic plasma concentration range of caffeine could not be determined from the placebo-controlled clinical trial. 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Medically reviewed by Drugs.com. Our caffeine is absolutely on point. Apnea of prematurity was defined as having at least 6 apnea episodes of greater than 20 seconds duration in a 24-hour period with no other identifiable cause of apnea. There will be extra medicine left in the vial after one dose is removed. Discard unused portion. Mio MiO Liquid Water Enhancer Drink Mix (1.62 Bottle), Berry Pomegranate, 1.63 Fl Oz, Mio Energy Black Cherry Liquid Water Enhancer Drink Mix (1.62 fl oz Bottles, Pack Of 12), True Lime Bulk Dispenser Pack, 100 Count (2.82oz), Stur - Classic Variety Pack, Natural Water Enhancer (5 Bottles, Makes 100 Flavored Waters) - Sugar Free, Zero Calories, Kosher, Keto Friendly Liquid Drink Mix Sweetened with Stevia, SodaStream Fruit Drops Citrus Variety Pack Drink Mixes, 1.36 fl. Caffeine Citrate Oral Solution,USP 60 mg/3 mL is a clear, colorless aqueous solution, 10 vials per white polypropylene child-resistant container and is available as follows. Therefore, caffeine has the potential to interact with drugs that are substrates for CYP1A2, inhibit CYP1A2, or induce CYP1A2. Distribution: Caffeine is rapidly distributed into the brain. Based on adult data, lower doses of caffeine may be needed following coadministration of drugs which are reported to decrease caffeine elimination (e.g., cimetidine and ketoconazole) and higher caffeine doses may be needed following coadministration of drugs that increase caffeine elimination (e.g., phenobarbital and phenytoin). Published long- term follow-up studies have not shown caffeine to adversely affect neurological development or growth parameters. Interconversion between caffeine and theophylline has been reported in preterm neonates; caffeine levels are approximately 25% of theophylline levels after theophylline administration and approximately 3-8% of caffeine administered would be expected to convert to theophylline. oz. For example, caffeine increases your heart rate, promotes wakefulness and alleviates fatigue, sharpens your focus an… Choose between our two flavors: Regular or Sweet. The safety and efficacy of caffeine citrate longer periods of treatment have not been established. The percentage of patients without apnea on day 2 of treatment (24 to 48 hours after the loading dose) was significantly greater with caffeine citrate than placebo. Vials containing discolored solution or visible particulate matter should be discarded. NOTE THAT THE DOSE OF CAFFEINE BASE IS ONE-HALF THE DOSE WHEN EXPRESSED AS CAFFEINE CITRATE (e.g., 20 mg of caffeine citrate is equivalent to 10 mg of caffeine base). Bangalore-560 099, INDIA. After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested in. Interconversion between caffeine and theophylline has been reported in preterm neonates. Caffeine administered concurrently with ketoprofen reduced the urine volume in 4 healthy volunteers. Your workouts will be tad more intense and power packed with pure caffeinated water. Kaffn8 Liquid Caffeine (20-Pack) Sale! Caffeine Citrate should be used with caution in infants with seizure disorders. The best way to get your liquid water is … from water. Green Tea Extract | 2 fl oz | Super Concentrated Liquid Supplement | Alcohol Free, Vegetarian, Non-G… Here, we will provide an overview of the active ingredients and highlight any pertinent research. They make an Orange Vanilla which some of you might remember the taste of a 'dreamsicle' which makes an awesome water … After you remove your baby’s dose, throw away the vial and all medicine left in the opened vial. Caffeine (as caffeine base) administered to male rats at 50 mg/kg/day subcutaneously (approximately equal to the maximum recommended intravenous loading dose for infants on a mg/m2 basis) for four days prior to mating with untreated females, caused decreased male reproductive performance in addition to causing embryotoxicity. Preservative Free. There are no adequate and well-controlled studies in pregnant women. Simply throw a couple packets … Apnea of prematurity is a diagnosis of exclusion. Call your baby’s doctor right away if your baby develops: This is not a complete list of side effects reported with Caffeine Citrate Oral Solution. Continue to push the syringe plunger up to remove any extra medicine in the syringe, until only the exact number of milliliters (or cubic centimeters) that your baby’s doctor prescribed remains in the syringe. You can also mix it with 5 grams of creatine for an intra workout that‚ will leave an impact. Caffeine Citrate Oral Solution is a clear, colorless, medicine to treat apnea of prematurity - short periods when premature babies stop breathing. Although no cases of cardiac toxicity were reported in the placebo-controlled trial, caffeine has been shown to increase heart rate, left ventricular output, and stroke volume in published studies. Description. Armas Pharmaceuticals, Inc. Your baby may or may not develop side effects from taking Caffeine Citrate Oral Solution. Do not use vials that contain cloudy or discolored medicine, or any visible particles. Consult your physician if the baby continues to have apnea events; do not increase the dose of caffeine citrate without medical consultation. How much caffeine is in Excedrin Migraine? Safety and efficacy of Caffeine Citrate Oral Solution for use in the prophylaxis treatment of sudden infant death syndrome (SIDS) or prior to extubation in mechanically ventilated infants have also not been established. Water Joe is energy at its simplest form: Water + Caffeine. This product comes with a dispensing pump for accurate servings of Liquid Caffeine. Your baby’s doctor, nurse or pharmacist will give you this small syringe. It is a bronchial smooth muscle relaxant, a CNS stimulant, a cardiac muscle stimulant and a diuretic. Therefore, serum glucose may need to be periodically monitored in infants receiving caffeine citarte. It’s found in the heart, brain, retina and many other parts of the body where the body needs it. Read the following information before giving this medicine to your baby. It helps to provide sustained energy output for those times you really need to go the distance. Continue to discuss any questions you have about this medicine at your baby’s checkups. Caffeine Citrate Oral Solution, USP vials contain 3 mL solution at a concentration of 20 mg/mL caffeine citrate (60 mg/vial) equivalent to 10 mg/mL caffeine base (30 mg/vial). Press the two tabs and raise the cover up. 50% polyester/25% cotton/25% Rayon Available in Small - XL. Two were randomized to caffeine, and one placebo patient was “rescued” with open-label caffeine for uncontrolled apnea. Note that a milliliter (ml) is the same as a cubic centimeter (cc). The recommended loading dose and maintenance doses of caffeine citrate follow. Caffeine also potentiated the genotoxicity of known mutagens and enhanced the micronuclei formation (5-fold) in folate-deficient mice. ADVERSE EVENTS THAT OCCURRED MORE FREQUENTLY IN CAFFEINE CITRATE TREATED PATIENTS THAN PLACEBO DURING DOUBLE-BLIND THERAPY, SPECIAL SENSES As pentobarbital sodium and long-term neurological sequelae has been reported that are substrates for CYP1A2, inhibit CYP1A2, any! Discuss any questions you have a concern about your baby ’ s doctor, nurse or pharmacist the... Have a concern about your baby once a day, at about same! 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